Direct sampling of the Susskind-Glogower phase distributions

Coarse-grained phase distributions are introduced that approximate to the Susskind--Glogower cosine and sine phase distributions. The integral relations between the phase distributions and the phase-parametrized field-strength distributions observable in balanced homodyning are derived and the integral kernels are analyzed. It is shown that the phase distributions can be directly sampled from the field-strength distributions which offers the possibility of measuring the Susskind--Glogower cosine and sine phase distributions with sufficiently well accuracy. Numerical simulations are performed to demonstrate the applicability of the method.Comment: 10 figures using a4.st

Frictional Drag between Two Dilute Two-Dimensional Hole Layers

We report drag measurements on dilute double layer two-dimensional hole systems in the regime of r_s=19~39. We observed a strong enhancement of the drag over the simple Boltzmann calculations of Coulomb interaction, and deviations from the T^2 dependence which cannot be explained by phonon-mediated, plasmon-enhanced, or disorder-related processes. We suggest that this deviation results from interaction effects in the dilute regime.Comment: 4 pages, 3 figures, accepted in Phys. Rev. Lett. Added single layer transport dat

Magnetic Field Induced Insulating Phases at Large rsr_s

Exploring a backgated low density two-dimensional hole sample in the large $r_s$ regime we found a surprisingly rich phase diagram. At the highest densities, beside the $\nu=1/3$, 2/3, and 2/5 fractional quantum Hall states, we observe both of the previously reported high field insulating and reentrant insulating phases. As the density is lowered, the reentrant insulating phase initially strengthens, then it unexpectedly starts weakening until it completely dissapears. At the lowest densities the terminal quantum Hall state moves from $\nu=1/3$ to $\nu=1$. The intricate behavior of the insulating phases can be explained by a non-monotonic melting line in the $\nu$-$r_s$ phase space

Loss of the PTCH1 tumor suppressor defines a new subset of plexiform fibromyxoma.

BackgroundPlexiform fibromyxoma (PF) is a rare gastric tumor often confused with gastrointestinal stromal tumor. These so-called "benign" tumors often present with upper GI bleeding and gastric outlet obstruction. It was recently demonstrated that approximately one-third of PF have activation of the GLI1 oncogene, a transcription factor in the hedgehog (Hh) pathway, via a MALAT1-GLI1 fusion protein or GLI1 up-regulation. Despite this discovery, the biology of most PFs remains unknown.MethodsNext generation sequencing (NGS) was performed on formalin-fixed paraffin-embedded (FFPE) samples of PF specimens collected from three institutions (UCSD, NCI and OHSU). Fresh frozen tissue from one tumor was utilized for in vitro assays, including quantitative RT-PCR and cell viability assays following drug treatment.ResultsEight patients with PF were identified and 5 patients' tumors were analyzed by NGS. An index case had a mono-allelic PTCH1 deletion of exons 15-24 and a second case, identified in a validation cohort, also had a PTCH1 gene loss associated with a suspected long-range chromosome 9 deletion. Building on the role of Hh signaling in PF, PTCH1, a tumor suppressor protein, functions upstream of GLI1. Loss of PTCH1 induces GLI1 activation and downstream gene transcription. Utilizing fresh tissue from the index PF case, RT-qPCR analysis demonstrated expression of Hh pathway components, SMO and GLI1, as well as GLI1 transcriptional targets, CCND1 and HHIP. In turn, short-term in vitro treatment with a Hh pathway inhibitor, sonidegib, resulted in dose-dependent cell killing.ConclusionsFor the first time, we report a novel association between PTCH1 inactivation and the development of plexiform fibromyxoma. Hh pathway inhibition with SMO antagonists may represent a target to study for treating a subset of plexiform fibromyxomas

Optical Study of the Free Carrier Response of LaTiO3/SrTiO3 Superlattices

We used infrared spectroscopic ellipsometry to investigate the electronic properties of LaTiO3/SrTiO3 superlattices (SLs). Our results indicated that, independent of the SL periodicity and individual layer-thickness, the SLs exhibited a Drude metallic response with sheet carrier density per interface ~3x10^14 cm^-2. This is probably due to the leakage of d-electrons at interfaces from the Mott insulator LaTiO3 to the band insulator SrTiO3. We observed a carrier relaxation time ~ 35 fs and mobility ~ 35 cm^2V^-1s^-1 at 10 K, and an unusual temperature dependence of carrier density that was attributed to the dielectric screening of quantum paraelectric SrTiO3.Comment: 4 pages, 4 figure

Data clustering and noise undressing for correlation matrices

We discuss a new approach to data clustering. We find that maximum likelihood leads naturally to an Hamiltonian of Potts variables which depends on the correlation matrix and whose low temperature behavior describes the correlation structure of the data. For random, uncorrelated data sets no correlation structure emerges. On the other hand for data sets with a built-in cluster structure, the method is able to detect and recover efficiently that structure. Finally we apply the method to financial time series, where the low temperature behavior reveals a non trivial clustering.Comment: 8 pages, 5 figures, completely rewritten and enlarged version of cond-mat/0003241. Submitted to Phys. Rev.

Frictional drag between non-equilibrium charged gases

The frictional drag force between separated but coupled two-dimensional electron gases of different temperatures is studied using the non-equilibrium Green function method based on the separation of center-of-mass and relative dynamics of electrons. As the mechanisms of producing the frictional force we include the direct Coulomb interaction, the interaction mediated via virtual and real TA and LA phonons, optic phonons, plasmons, and TA and LA phonon-electron collective modes. We found that, when the distance between the two electron gases is large, and at intermediate temperature where plasmons and collective modes play the most important role in the frictional drag, the possibility of having a temperature difference between two subsystems modifies greatly the transresistivity.Comment: 8figure

Direct sampling of exponential phase moments of smoothed Wigner functions

We investigate exponential phase moments of the s-parametrized quasidistributions (smoothed Wigner functions). We show that the knowledge of these moments as functions of s provides, together with photon-number statistics, a complete description of the quantum state. We demonstrate that the exponential phase moments can be directly sampled from the data recorded in balanced homodyne detection and we present simple expressions for the sampling kernels. The phase moments are Fourier coefficients of phase distributions obtained from the quasidistributions via integration over the radial variable in polar coordinates. We performed Monte Carlo simulations of the homodyne detection and we demonstrate the feasibility of direct sampling of the moments and subsequent reconstruction of the phase distribution.Comment: RevTeX, 8 pages, 6 figures, accepted Phys. Rev.

Resonant inelastic x-ray scattering study of holon-antiholon continuum in SrCuO2

We report a resonant inelastic x-ray scattering study of charge excitations in the quasi-one-dimensional Mott insulator SrCuO2. We observe a continuum of low-energy excitations, in which a highly dispersive feature with a large sinusoidal dispersion (~1.1 eV) resides. We have also measured the optical conductivity, and studied the dynamic response of the extended Hubbard model with realistic parameters, using a dynamical density-matrix renormalization group method. In contrast to earlier work, we do not find a long-lived exciton, but rather these results suggest that the excitation spectrum comprises a holon-antiholon continuum together with a broad resonance.Comment: Final version to be published in Phys. Rev. Let